48 Hours in Santa Fe

Renowned for its rich cultural tapestry woven from Native American, Spanish, and Mexican traditions, Santa Fe entices travelers with its vibrant art, distinctive architecture, and bold Southwestern cuisine. From centuries-old adobe buildings to a thriving contemporary art scene, this high-desert haven offers more than enough magic to fill a 48-hour escape.

Sleep in style at this legendary Santa Fe hotel

Located directly on the historic Santa Fe Plaza—the city’s vibrant heart surrounded by shops, galleries, and street performers—the iconic dates back to the 1920s and has been a cultural landmark ever since. This AAA Four Diamond property is beloved for its blend of traditional Southwestern architecture and modern luxury. La Fonda boasts colorful tilework, hand-carved furniture, and an epic art collection displayed throughout its public and private spaces. It’s been a gathering place for artists, writers, politicians, and visitors for over a century and remains a quintessential Santa Fe getaway.

Discover Santa Fe’s cultural highlights

Santa Fe Plaza is the historic heart of the city and a perfect starting point for your visit. This lively hub is home to the Palace of the Governors, where you can explore New Mexico’s layered history and shop for Native American crafts from local artisans beneath its iconic portal. The Plaza is surrounded by charming boutiques, galleries, and cafés, making it a fun place for people-watching, too.

Just a few minutes’ walk from The Plaza, Loretto Chapel is known for its intricate Gothic Revival design—but especially for its “miraculous staircase,” a 33-step spiral with no visible means of support and constructed without nails. Step inside for a peaceful escape, and learn about one of Santa Fe’s most enduring mysteries.

And if you’re visiting in summer, the world-renowned Santa Fe Opera is a must. Nestled in the foothills just north of the city, this open-air venue is as famous for its dramatic desert sunsets and mountain views as it is for its innovative productions. From classic repertoire to contemporary premieres, the opera draws fans from around the globe—and the experience is unforgettable, whether you're an aficionado or a first-timer.

Delve into Santa Fe’s art scene

Much of modern Santa Fe feels like an upscale artist colony, and Canyon Road is its creative epicenter. This world-renowned arts district is home to more than 100 galleries. The hallmark adobe architecture and abundant outdoor sculptures create a captivating atmosphere for an inspiring stroll—whether or not you’re in the market for a new piece. 

While there are excellent museums scattered throughout the city, Museum Hill is a concentrated collection worth visiting. This enclave is home to four world-class institutions: the Museum of Indian Arts & Culture, the Museum of International Folk Art, the Wheelwright Museum of the American Indian, and the Museum of Spanish Colonial Art. Together, they offer a deep dive into Native American history, global folk art traditions, and the region’s colonial heritage. The Santa Fe Botanical Garden, with its walking trails and high-desert flora, adds a peaceful counterpoint to the indoor exhibits.

Back downtown, don’t miss the Georgia O’Keeffe Museum, one of Santa Fe’s most-visited attractions. It houses more than 3,000 works by the world-famous artist and houses holds the largest O’Keeffe collection in the world. Daily timed-entry tickets are limited, so advanced reservations are strongly recommended. 

For those looking to dedicate an entire day to Santa Fe’s art scene, here’s a valuable tip: the free Santa Fe Pickup shuttle circulates between the Georgia O’Keeffe museum, Museum Hill, and Canyon Road.

For an otherworldly experience, step into Meow Wolf’s House of Eternal Return. This immersive, multisensory art installation, which originated in Santa Fe, combines surreal environments, interactive storytelling, and hands-on creativity. It’s easy to lose track of time exploring the rooms—so if you’re on a tight schedule, be sure to keep an eye on the clock.

Try these top Santa Fe bites

The Pantry, a cherished local spot known for its homey atmosphere, is the place to go for a hearty breakfast before exploring the city. The huevos rancheros are a standout choice and a true taste of New Mexico—served on crispy tortillas and smothered in rich, spicy green chile sauce.

At lunch, head to Cafe Pasqual’s, where the eclectic menu of creative updates to traditional Southwestern ingredients offers one of the most flavorful experiences in town. Try the famous blue corn enchiladas filled with roasted chicken and topped with a tangy red chile sauce. You’ll soon learn about the local rivalry between supporters of green chile versus red chile. It’s a debate that’s both low-key and fiercely loyal; try them both, and choose your side.

The Compound Restaurant, a AAA Four Diamond restaurant, is another great choice for lunch, serving a refined take on classic Southwestern cuisine. The grilled pork tenderloin with a red chile glaze and seasonal vegetables highlights the restaurant’s emphasis on local, high-quality ingredients. The elegant yet relaxed atmosphere makes it ideal for a leisurely meal.

For dinner, indulge in a sophisticated dining experience at another AAA Four Diamond restaurant in town: Geronimo. Known for its creative cuisine and refined adobe setting, Geronimo consistently impresses. The grilled beef tenderloin—whether it’s featured on the menu as prepared with a mornay sauce with smoked bacon or a port wine reduction—is a guest favorite. Exceptional service and a romantic atmosphere make it a memorable choice for a special occasion. 

For a more casual dinner, head to La Choza Restaurant, a local hotspot known for its lively atmosphere and authentic New Mexican flavors. Its signature dish is the carne adovada—tender pork or chicken marinated in a red or green chile sauce and served with pinto beans, posole lettuce, and tomato.

If you’re a meat eater, one iconic bite you shouldn’t miss in Santa Fe is the legendary Frito pie, served right where many claim it was first created. While some Texans contest the origin story, Santa Fe proudly stakes its claim: In the 1960s, a Woolworth’s lunch counter on the Plaza started serving a spicy blend of meaty red chile and ground beef ladled straight into an open bag of Fritos and topped with cheese. That counter lives on at the Five & Dime General Store, where you can still grab this no-frills, flavor-packed snack.

From the first bite to the last sunset, Santa Fe weaves a rich tapestry of culture and spirit—so enticing, you may want to stay well beyond 48 hours to uncover more of its magic.